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Who is
Majid Ali, M.D.
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Dr. Ali's CV
Majid Ali is a
pioneer who is changing the face of medicine with his
innovative and spirited approach.
His credentials are
impeccable
Complementary Medicine Journal
"I stand in awe of Ali's
superb scientific knowledge, his insights into the nature of
the the healing process and his ability to explain hard
science."
Aubrey Worrell, MD
Past President, the American Academy of
Environmental Medicine
Majid Ali,
M.D.
Editor,
The Journal of Integrative Medicine
Formerly, Associate Professor of Pathology (adj.), College
of Physicians and Surgeons of Columbia University, NY
Formerly, President of Staff and
Chief Pathologist, Holy Name Hospital, Teaneck, NJ
Fellow, Royal College of Surgeons of England
- Diplomate,
American Board of Anatomic and Clinical Pathology
Diplomate, American Boards of Environmental Medicine
Past President Capital University of Integrative
Medicine
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Uric Acid and Gout
Recently, a colleague, told me that her mother in India saw
an orthopedic surgeon for chronic arthritis pain in her
knees and hips. The doctor noted an elevated blood uric acid
value and promptly prescribed five drugs, including a
high-dose steroid level. When my colleague protested that
her mother did not have gout but osteoarthritis, the
orthopod shrugged her off by saying, “This is our standard
treatment for treating high uric acid levels.”
I asked fifteen practitioners (five physicians, one nurse,
one physician assistant, two nutrition advisors, four
laboratory technologists, and two administrative staff
members) to answer the following two questions:
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What is your general sense
about vitamin C, is it a good player or a bad player?
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What is your general sense
about uric acid, is it a good player or a bad player?
Thirteen called vitamin C a good player and considered uric
acid to be a bad player. The remaining two said uric acid
could go either way. That did not surprise me since uric
acid is embedded deep in drug medicine thinking as a
villain. A raised blood uric acid level is used to diagnose
gout arthritis, as well as to detect an increased risk of
heart attacks and strokes. This is what medical textbooks
teach medical students and doctors. Next, I wondered what
the oxygen prism and Darwin might have to say about uric
acid.
Killing the Messenger
Uric acid is a marker of tissue injury. Rising blood levels
herald pathologic inflammation that causes cell death. When
I see elevated blood uric acid level in my patients’ lab
reports, I see it as injured cells’ call for relief. To me
this the lab abnormality requires diligent efforts to detect
and eliminate all relevant insults to the body. I do not see
uric acid as an evil player that must be snuffed with drugs.
Uric Acid Is a Potent Antioxidant
Over half the antioxidant capacity of human blood plasma is
derived from uric acid. It is is fifty-fold stronger
antioxidant than vitamin C. So, if we consider vitamin C to
be a good player, we must consider uric acid as fifty times
as good. Why is this fact not generally known? The answer:
no drug company or medical journal profits from
disseminating this information.
Uric acid has been successfully employed in the prevention
and treatment of an animal model of multiple sclerosis. A
2006 study found that oral use of inosine raised serum uric
acid values in patients with this disease, without causing
any adverse effects. It does not surprise me that this
nutritional possibility for multiple sclerosis was not
explored further since no one can make obscene profits from
it.
Uric Acid Is An Immune Booster
This is likely to surprise nearly all readers. I myself
never considered uric acid biology in a broader context
during the first twenty-five years of my work as a surgeon
and pathologist. This is gift of understanding from my
patients. They forced me to think differently when I
recognized how they responded to overhydration and nondrug
therapies (listed below) that normalize the inflammatory
response by focusing on ecologic disruptions of the bowel,
blood, and liver
ecosystems.
Uric Acid Facilitates Cross-talk Between Dead and
Living cells
Uric acid is a principal endogenous danger signal released
from dead and dying cells. This basic but generally
unrecognized fact of uric acid biology calls for a major
shift in the way we look at it. Uric acid stimulates a type
of immune cell (dendritic cell) to its maturation. When such
cells are injected along with certain substances in
experimental animals, another type of immune cell (CD8+ T
cell) becomes stronger in its responses to microbes and
noxious chemicals. In other experiments, removal of uric
acid weakens certain types of immune responses, indicating
immune- boosting effects of uric acid.
Why do blood uric acid levels rise?
What might be the basis of observed association between
raised uric acid levels and increased risks of insulin
resistance, diabetes, heart attacks, and strokes?
Uric acid is produced by the enzyme, xanthine oxidase, from
xanthine and hypoxanthine, which in turn are produced from
purine. Evolutionary design for the redox systems in living
organisms is simple: if you increase oxidative stress, the
antioxidant systems are upregulated. When the body is
insulted by the trio of toxicities of foods, environments,
and thoughts—the trio that sets the stage for insulin
toxicity, the so-called metabolic syndrome, heart attacks,
strokes, and gouty arthritis—the body gears up its
antioxidant defenses. Uric acid, a potent weapon in the
body’s antioxidant armamentarium, is produced in excess to
cope with incremental oxidative stress. So, the blood uric
acid levels go up. It is not the body’s cries for drugs,
only for relief from the trio of toxicities.
Prevention and Treatment of Gout
Inflammation in acute gout arthritis is caused by the trio
of toxicities of foods, environments, and thoughts. The
rational and scientific approach to the prevention and
treatment of gout is to systematically identify and address
all relevant elements of toxicity. In decades of clinical
work, I have not found any natural remedy that by itself
gives good long-term results. My preferred therapies are:
(1) castor-pres; (2) hydrogen peroxide foot soaks; (3)
optimal hydration; (4) control of gut fermentation and leaky
gut state; (5) and liver detox. Some dietary measures are
very helpful. Uric acid is derived from compounds called
purines, which are found in large amounts in animal food
products, such as liver, kidneys, and sardines. Lesser
amounts are in pork, beef, poultry, seafood, and certain
vegetables (asparagus, cauliflower, spinach, mushrooms, and
green peas), and certain grains (oatmeal, wheat bran and
wheat germ). So, it is advisable to eliminate these items
during acute attacks, and reduce their intake in general.
In drug medicine, symptoms are managed with nonsteroidal
anti-inflammatory drugs (NSAIDs), steroids, and colchicine.
These approaches can be justified only in unusual
circumstances for short periods of time to relieve acute
symptoms that cannot be rapidly controlled with nondrug
therapies. |
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NOW
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The classic work
on the subject
E-Book 560 pages
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Integrative Protocols -
Vol 12 Principles and
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E-Book price $35
Book price $95
Integrative Protocols -
Vol 11 Principles and
Practices
of Integrative Medicine
E-Book price $35
Book price $95
Dr.
Ali discusses Dysoxygenosis and varying
chronic diseases.
Chapter 1 Under Darwin’s Glow
Chapter 2 Energy Deficit States
Chapter 3 Integration
Chapter 4 The Oxygen Order of Life
Chapter 5 Oxygen
Chapter 6 Aging
Chapter 7 Inflammation
Chapter 8 Pain
Chapter 9 Heart Disease
Chapter 10 Asthma
Chapter 11 Renal Insufficiency
Chapter 12 Osteoporosis
Chapter 13 Metalicised Mouths
Chapter 14 Hormone Disorders
Chapter 15 Arrested Growth |
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